![](data:image/svg+xml,<svg display="block" role="presentation" viewBox="0 0 174 36" xmlns="http://www.w3.org/2000/svg"><path d="M 32.455 26.308 C 31.204 28.543 28.367 29.344 26.131 28.093 C 25.858 27.94 25.6 27.76 25.366 27.557 C 25.32 27.518 25.271 27.484 25.22 27.456 C 24.96 27.311 24.641 27.303 24.371 27.447 C 24.049 27.619 23.865 27.971 23.908 28.334 C 24.083 29.781 23.799 31.22 23.085 32.493 C 21.238 35.793 17.05 36.974 13.75 35.127 C 12.597 34.482 11.662 33.525 11.045 32.361 C 10.444 31.226 10.172 29.95 10.258 28.671 C 10.281 28.33 10.104 28.007 9.807 27.84 C 9.797 27.835 9.787 27.829 9.777 27.824 C 9.462 27.663 9.081 27.705 8.809 27.931 C 8.094 28.525 7.224 28.889 6.293 28.982 C 5.343 29.079 4.4 28.882 3.565 28.415 C 1.33 27.165 0.529 24.329 1.78 22.094 C 2.325 21.12 3.204 20.376 4.256 19.997 C 4.6 19.872 4.833 19.548 4.84 19.182 C 4.846 18.853 4.67 18.551 4.388 18.393 C 4.355 18.375 4.322 18.358 4.287 18.344 C 4.022 18.237 3.76 18.111 3.508 17.97 C 0.207 16.123 -0.975 11.937 0.873 8.638 C 2.72 5.339 6.908 4.156 10.209 6.003 C 10.46 6.144 10.705 6.302 10.935 6.472 C 10.966 6.494 10.997 6.514 11.029 6.532 C 11.311 6.69 11.661 6.683 11.938 6.505 C 12.247 6.308 12.402 5.94 12.328 5.581 C 12.101 4.487 12.276 3.349 12.821 2.375 C 14.073 0.14 16.91 -0.66 19.145 0.591 C 19.98 1.058 20.641 1.759 21.056 2.618 C 21.462 3.46 21.607 4.391 21.475 5.311 C 21.424 5.661 21.588 6.008 21.89 6.192 C 21.899 6.198 21.909 6.204 21.919 6.209 C 22.216 6.375 22.584 6.356 22.863 6.158 C 23.908 5.416 25.138 4.982 26.421 4.9 C 27.737 4.817 29.041 5.114 30.194 5.759 C 33.495 7.605 34.677 11.792 32.829 15.091 C 32.116 16.364 31.039 17.359 29.713 17.967 C 29.381 18.119 29.176 18.46 29.198 18.824 C 29.217 19.129 29.39 19.398 29.65 19.543 C 29.701 19.572 29.755 19.595 29.813 19.614 C 30.108 19.708 30.397 19.834 30.67 19.986 C 32.905 21.237 33.706 24.074 32.455 26.308 Z M 21.972 11.014 C 21.077 12.613 21.647 14.634 23.247 15.529 C 24.847 16.424 26.869 15.854 27.765 14.255 C 28.66 12.656 28.089 10.634 26.489 9.739 C 24.89 8.844 22.867 9.415 21.972 11.014 Z M 15.143 5.003 C 14.606 5.963 14.948 7.176 15.908 7.713 C 16.868 8.25 18.082 7.907 18.619 6.948 C 19.156 5.988 18.813 4.775 17.854 4.239 C 16.894 3.701 15.681 4.044 15.143 5.003 Z M 7.1 16.076 C 8.699 16.971 10.722 16.4 11.617 14.801 C 12.513 13.202 11.942 11.18 10.342 10.285 C 8.743 9.391 6.72 9.961 5.825 11.56 C 4.929 13.159 5.5 15.181 7.1 16.076 Z M 8.691 24.655 C 9.228 23.696 8.885 22.482 7.926 21.945 C 6.966 21.409 5.753 21.751 5.215 22.71 C 4.678 23.669 5.021 24.883 5.981 25.42 C 6.94 25.957 8.154 25.614 8.691 24.655 Z M 20.045 28.583 C 20.941 26.984 20.37 24.962 18.77 24.067 C 17.17 23.172 15.148 23.743 14.253 25.342 C 13.357 26.941 13.928 28.963 15.528 29.858 C 17.127 30.753 19.15 30.182 20.045 28.583 Z M 24.346 21.771 C 24.725 21.094 25.271 20.519 25.927 20.109 C 26.237 19.915 26.395 19.551 26.326 19.192 C 26.276 18.931 26.113 18.712 25.889 18.587 C 25.805 18.54 25.713 18.506 25.615 18.488 C 24.872 18.354 24.158 18.097 23.494 17.725 C 22.131 16.963 21.062 15.745 20.481 14.295 C 19.909 12.865 19.832 11.27 20.263 9.806 C 20.363 9.466 20.251 9.099 19.979 8.874 C 19.937 8.84 19.893 8.809 19.847 8.784 C 19.591 8.64 19.277 8.632 19.009 8.769 C 17.617 9.485 15.972 9.46 14.611 8.7 C 14.291 8.521 13.893 8.558 13.612 8.793 C 13.33 9.028 13.223 9.412 13.343 9.759 C 13.977 11.606 13.795 13.639 12.844 15.336 C 11.894 17.033 10.255 18.251 8.349 18.677 C 7.991 18.756 7.72 19.049 7.666 19.411 C 7.613 19.774 7.789 20.132 8.109 20.312 C 9.469 21.074 10.351 22.462 10.468 24.023 C 10.491 24.323 10.662 24.586 10.918 24.729 C 10.964 24.755 11.014 24.777 11.064 24.794 C 11.399 24.909 11.771 24.813 12.008 24.55 C 13.031 23.416 14.431 22.648 15.95 22.388 C 17.49 22.124 19.088 22.399 20.451 23.161 C 21.115 23.533 21.707 24.007 22.211 24.569 C 22.277 24.644 22.354 24.705 22.438 24.751 C 22.661 24.876 22.934 24.901 23.183 24.807 C 23.524 24.679 23.752 24.353 23.756 23.988 C 23.762 23.215 23.967 22.449 24.347 21.771 Z M 29.008 24.38 C 29.545 23.421 29.202 22.207 28.243 21.67 C 27.283 21.133 26.069 21.476 25.532 22.435 C 24.995 23.395 25.337 24.608 26.297 25.145 C 27.257 25.682 28.47 25.34 29.008 24.38 Z" fill="rgb(10, 15, 26)" height="35.99998404676664px" id="L9i9lfmGB" transform="translate(0 0)" width="33.70212491897429px"/><path d="M 5.764 19.383 L 0 0 L 2.734 0 L 6.273 11.849 C 6.541 12.868 6.809 13.887 7.077 15.361 C 7.399 13.806 7.694 12.868 7.989 11.849 L 11.662 0 L 14.503 0 L 18.149 11.849 C 18.471 12.895 18.739 13.914 19.034 15.361 C 19.356 13.726 19.624 12.734 19.892 11.876 L 23.457 0 L 26.138 0 L 20.294 19.383 L 17.774 19.383 L 13.083 4.048 L 8.337 19.383 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="iCH2wvtmH" transform="translate(42.701 8.322)" width="26.1383px"/><path d="M 6.568 11.501 L 0 0 L 2.949 0 L 7.265 7.748 C 7.533 8.203 7.694 8.579 7.909 9.034 C 8.15 8.552 8.203 8.391 8.552 7.748 L 12.841 0 L 15.71 0 L 9.195 11.501 L 9.195 19.383 L 6.568 19.383 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="l1jcMQyEW" transform="translate(68.702 8.322)" width="15.709800000000001px"/><path d="M 2.627 19.383 L 0 19.383 L 0 0 L 2.627 0 L 12.546 14.986 L 12.546 0 L 15.173 0 L 15.173 19.383 L 12.546 19.383 L 2.627 4.397 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="PuuQLPXs7" transform="translate(86.14 8.322)" width="15.173200000000008px"/><path d="M 7.373 19.383 L 0 0 L 2.815 0 L 7.533 12.386 C 7.962 13.485 8.338 14.584 8.74 16.031 C 9.195 14.503 9.651 13.217 9.973 12.359 L 14.664 0 L 17.399 0 L 10.107 19.383 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="LZpnHzXku" transform="translate(103.039 8.322)" width="17.399px"/><path d="M 11.823 19.383 L 0 19.383 L 0 0 L 11.823 0 L 11.823 2.413 L 2.627 2.413 L 2.627 8.471 L 10.911 8.471 L 10.911 10.804 L 2.627 10.804 L 2.627 16.943 L 11.823 16.943 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="PY7hKwFi7" transform="translate(122.152 8.322)" width="11.822999999999993px"/><path d="M 2.628 19.383 L 0 19.383 L 0 0 L 7.319 0 C 11.475 0 13.941 2.198 13.941 5.817 C 13.941 8.498 12.6 10.429 10.188 11.206 L 14.129 19.383 L 11.206 19.383 L 7.587 11.715 L 2.628 11.715 Z M 2.628 2.359 L 2.628 9.383 L 7.346 9.383 C 9.786 9.383 11.18 8.069 11.18 5.844 C 11.18 3.592 9.732 2.359 7.319 2.359 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="CI8cAX3SV" transform="translate(136.977 8.322)" width="14.12899999999999px"/><path d="M 2.627 0 L 2.627 19.383 L 0 19.383 L 0 0 Z" fill="rgb(10, 15, 26)" height="19.382559999999998px" id="iTXkSnT3f" transform="translate(153.714 8.322)" width="2.6270000000000095px"/><path d="M 0.268 5.576 C 0.268 2.252 2.949 0 6.943 0 C 10.643 0 13.029 2.064 13.243 5.415 L 10.589 5.415 C 10.455 3.485 9.088 2.359 6.916 2.359 C 4.477 2.359 2.895 3.592 2.895 5.496 C 2.895 7.051 3.78 7.989 5.603 8.418 L 8.793 9.168 C 11.956 9.892 13.565 11.608 13.565 14.343 C 13.565 17.828 10.857 20.053 6.729 20.053 C 2.788 20.053 0.161 17.988 0 14.664 L 2.681 14.664 C 2.734 16.514 4.289 17.694 6.729 17.694 C 9.302 17.694 10.938 16.487 10.938 14.557 C 10.938 13.029 10.107 12.064 8.257 11.635 L 5.067 10.911 C 1.903 10.187 0.268 8.364 0.268 5.576 Z" fill="rgb(10, 15, 26)" height="20.05277px" id="Hkn9knIuz" transform="translate(158.663 7.974)" width="13.564999999999998px"/></svg>)
Towards Wnt inhibition without prohibitive toxicity
Towards Wnt inhibition without prohibitive toxicity
Wnt fuels cancer growth and drug resistance in millions of patients each year - yet any attempts to drug it have been blocked by toxicity.
Wnt fuels cancer growth and drug resistance in millions of patients each year - yet any attempts to drug it have been blocked by toxicity.
The Problem
Broad Wnt inhibition is overly toxic
Blocking Wnt signaling broadly leads to dose-limiting toxicity especially in gut and bone
Implicated across all major solid tumors
The Problem
Wnt drives cancer drug resistance
Blocking Wnt signaling broadly leads to dose-limiting toxicity especially in gut and bone
Implicated across all major solid tumors
The Limitation
Dose-limiting bottleneck
Narrow therapeutic window especially limiting in drug combinations
No approved Wnt inhibitor drug
The Limitation
Dose-limiting bottleneck
Narrow therapeutic window especially limiting in drug combinations
No approved Wnt inhibitor drug
The Innovation
Receptor Selective Inhibition
Targeting the specific Wnt receptor a tumor relies on for survival and resistance
Healthy tissue can rely on other receptors
The Innovation
Receptor Selective Inhibition
Targeting the specific Wnt receptor a tumor relies on for survival and resistance
Healthy tissue can rely on other receptors
The Opportunity
Engineered For Tolerability
First-in-class Wnt inhibitor molecule with a wide theraupetic window
Mono- and combination therapy potential
The Opportunity
Engineered For Tolerability
First-in-class Wnt inhibitor molecule with a wide theraupetic window
Mono- and combination therapy potential
Explore our preclinical data
Explore our
preclinical data
Book a call to meet a founder, learn more about our data, and discuss what selective Wnt inhibition could mean for oncology.
Book a call to meet a founder, learn more about our data, and discuss what selective Wnt inhibition could mean for oncology.
Phase 2
Phase 2
Phase 1
Phase 1
Pre-Clinical
Pre-Clinical
Research
Research
The Team
The Team
Pioneered by scientists with two decades and 8,000+ citations in Wnt research. Backed by business veterans.
Pioneered by scientists with two decades and 8,000+ citations in Wnt research. Backed by business veterans.
